Peptides For Hair Growth

Author: Dr. Blake Bloxham

Peptides have become a “buzzword” in the world of hair restoration. But seasoned hair loss sufferers know that popularity and “buzz” do not always equate to effective treatments. So many exciting therapies have “come and gone” in the world of hair loss, and it’s easy to be skeptical or even jaded when a new one comes along.

Peptides seem to be the hair restoration “flavor of the week,” but are they an ineffective fad or something else? What even is a peptide? How do they claim to work for hair loss? And are they safe for patients to use? This article answers these questions and more.  If you are interested in a “complete guide” to hair loss and peptides, read on!

Peptides are short chains made up of amino acids. Amino acids are the same building blocks our body uses to make proteins. If a chain is made up of less than 50 amino acids held together by “peptide bonds,” then it is a peptide; more than 50 amino acids and it is a protein.
Peptides play a critical role in signaling processes within the body. And many peptides are made naturally by our bodies. For example, crucial hormones including Oxytocin (allows for labor and breastfeeding), Growth Hormone, and Calcitonin (regulates blood calcium levels) — amongst others — are all peptides.
But not all peptides are natural occurring structures working daily inside our bodies. Many peptides are derived from other sources or created in a lab and used as medicinal treatments. This includes peptides used for hair loss and hair growth. From copper peptides to collagen peptides and injectable formulations, peptides are increasingly being explored as a solution for hair loss.

Copper peptides are among the most studied peptides for hair growth, and research suggests they can be effective in promoting healthier, thicker hair (Pyo et al., 2007).

These peptides work by improving scalp health and stimulating hair follicles through several mechanisms:

Angiogenesis:

Copper peptides help increase blood flow to hair follicles, ensuring they receive essential nutrients and oxygen.

Follicle Stimulation:

Copper peptides encourage the proliferation of hair follicle (dermal papilla) cells and discourage these same cells from “apoptosis” or natural cell turnover.

DHT Reduction:

Some studies indicate copper peptides may help inhibit the enzyme responsible for converting testosterone to dihydrotestosterone (DHT), a key contributor to androgenetic alopecia.

Collagen Production:

Copper peptides boost collagen and elastin production, enhancing scalp elasticity and skin quality.

While promising, Copper peptides are still experimental and require further testing.Furthermore, results can vary depending on the individual, the product used, and the severity of hair loss.

However, Copper peptides are available in several forms, including serums, shampoos, and topical solutions. They are often marketed as part of hair care products targeting hair thinning and scalp health.

Apply Topically:

Use a copper peptide serum directly on the scalp, focusing on areas of thinning hair.

Combine with Other Treatments:

Copper peptides can complement other treatments like minoxidil or microneedling.

Daily Use:

Consistent application, typically once or twice a day, yields the best results.

Collagen peptides work differently from copper peptides. Rather than acting directly on hair follicles, they improve overall scalp and hair health by:

Strengthening Hair:

Collagen provides essential amino acids that support keratin production, the protein that forms hair strands.

Improving Scalp Skin:

Collagen peptides hydrate and repair the scalp, creating a healthy environment for hair growth.

Reducing Hair Breakage:

By improving hair elasticity and strength, collagen peptides can minimize breakage and shedding.

Oral Supplements:

Collagen peptides are commonly taken as powders or capsules mixed with drinks or food.

Topical Products:

Some shampoos and conditioners are infused with collagen peptides for external application.

While collagen peptides may not directly stimulate new hair growth, they support the overall health of existing hair and scalp — which may minimize loss and create the appearance of thicker, fuller hair.

Injectable peptides are a more advanced option for those seeking targeted and potent hair restoration solutions. These are administered directly into the scalp by a trained healthcare professional.

GHK-Cu (Copper Tripeptide):

Boosts hair follicle activity and improves scalp health.

Thymosin Beta-4:

Supports tissue repair and promotes angiogenesis, aiding hair follicle regeneration.

BPC-157:

Known for its healing properties, it may help repair damaged scalp
tissue and improve follicle function.

Injectable peptides often show faster results than topical applications, but they require professional administration and may come with higher costs.

Furthermore, injectable peptides must be prepared by trusted sources and under sterile conditions. Patients must ask any provider offering peptide injections where they obtain the product and how much experience they have injecting it.

While peptides are generally well-tolerated, they are not without potential side effects, especially in injectable forms.

Skin Irritation:

Redness, itching, or mild irritation on the scalp.

Allergic Reactions:

Rare but possible, especially for those sensitive to specific peptide formulations.

Temporary Shedding:

Some users may experience increased hair shedding initially, a process called “hair cycling.”

Injection Risks:

Pain, swelling, or bruising at the injection site for injectable peptides.

How to Minimize Side Effects

Patch Test:

Before using topical peptides, conduct a patch test to check for allergies.

Professional Guidance:

Consult a dermatologist or trichologist before starting injectable peptide treatments.

Follow Instructions:

Use products as directed to avoid overuse or irritation.

Peptides offer an exciting avenue for hair growth, addressing hair loss through improved scalp health, follicle stimulation, and enhanced hair strength. Whether you opt for copper peptides, collagen peptides, or injectable formulations, the right approach depends on your specific needs and hair loss condition. Consult with a hair restoration expert to determine the most effective peptide-based treatment for you and ensure safe and optimal results.

Pyo, H.K. Et al. (2007). The effect of tripeptide-copper complex on human hair growth in
vitro. Arch Pharm Res. Jul;30(7):834-9. doi: 10.1007/BF02978833